Severe hydroxychloroquine myopathy
Identifieur interne : 001964 ( Main/Exploration ); précédent : 001963; suivant : 001965Severe hydroxychloroquine myopathy
Auteurs : Hoda Abdel-Hamid [États-Unis] ; Chester V. Oddis [États-Unis] ; David Lacomis [États-Unis]Source :
- Muscle & Nerve [ 0148-639X ] ; 2008-09.
English descriptors
- Teeft :
- Arterial blood, Bers, Brillation potentials, Chloroquine, Connective tissue diseases, Corticosteroid, Curvilinear, Curvilinear bodies, Deep tendon, Dyspnea, Early recognition, Endotracheal intubation, Expiratory volume, Hydroxychloroquine, Hydroxychloroquine myopathy, Hydroxychloroquine neuromyotoxicity, Hydroxychloroquine toxicity, Intensive care unit, Interstitial lung disease, Mechanical ventilation, Muscle biopsy, Muscle enzymes, Muscle nerve september, Muscle weakness, Myeloid bodies, Myopathy, Myotonic discharges, Myotoxic, Pittsburgh school, Pulmonary embolism, September, Severe hydroxychloroquine myopathy, Systemic lupus erythematosus, Toxic myopathy, Toxicity, Vacuolar myopathy, Vacuole, Ventilatory, Ventilatory failure, Vital capacity.
Abstract
Hydroxychloroquine causes a vacuolar myopathy that is usually of mild to moderate severity. The myopathy may be underrecognized, especially in patients who receive multiple other medications for complex illnesses. We report two patients with connective tissue diseases and unusually severe, histopathologically proven hydroxychloroquine myopathy. Both had ventilatory failure; one also had primary pulmonary disease associated with scleroderma, but the other lacked a pulmonary etiology. The ventilatory failure and subsequent medical complications led to death despite discontinuation of hydroxychloroquine, thereby underscoring the potential severity of hydroxychloroquine myopathy and the need for its early recognition. Muscle Nerve 38: 1206–1210, 2008
Url:
DOI: 10.1002/mus.21091
Affiliations:
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Le document en format XML
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The myopathy may be underrecognized, especially in patients who receive multiple other medications for complex illnesses. We report two patients with connective tissue diseases and unusually severe, histopathologically proven hydroxychloroquine myopathy. Both had ventilatory failure; one also had primary pulmonary disease associated with scleroderma, but the other lacked a pulmonary etiology. The ventilatory failure and subsequent medical complications led to death despite discontinuation of hydroxychloroquine, thereby underscoring the potential severity of hydroxychloroquine myopathy and the need for its early recognition. Muscle Nerve 38: 1206–1210, 2008</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Abdel Amid, Hoda" sort="Abdel Amid, Hoda" uniqKey="Abdel Amid H" first="Hoda" last="Abdel-Hamid">Hoda Abdel-Hamid</name></region><name sortKey="Lacomis, David" sort="Lacomis, David" uniqKey="Lacomis D" first="David" last="Lacomis">David Lacomis</name><name sortKey="Lacomis, David" sort="Lacomis, David" uniqKey="Lacomis D" first="David" last="Lacomis">David Lacomis</name><name sortKey="Lacomis, David" sort="Lacomis, David" uniqKey="Lacomis D" first="David" last="Lacomis">David Lacomis</name><name sortKey="Lacomis, David" sort="Lacomis, David" uniqKey="Lacomis D" first="David" last="Lacomis">David Lacomis</name><name sortKey="Oddis, Chester V" sort="Oddis, Chester V" uniqKey="Oddis C" first="Chester V." last="Oddis">Chester V. 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